::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

ALTERATIONS IN ANTI-MICROBIAL PROTEINS AND PRO-INFLAMMATORY CYTOKINES IN FEMALES OF ELDER AGE SUFFERING FROM IRON DEFICIENCY ANEMIA

AUTHORS:

Dr Hina Zahida, Dr Muhammad Akhtar, Dr Saneela Mussawar

ABSTRACT:

Objective: Iron Deficiency Anemia is very common issue of nutrition especially among females and it is also common in elder ages. Aging enhances the inflammatory mediator’s levels in plasma such as acute phase protein and pro-inflammatory cytokines. There is little information available about the alteration in the anti-microbial proteins in the females of elder age with iron deficiency anemia. In this current research work, we aimed to find out the alterations in the pro-inflammatory cytokines and recently identified anti-microbial proteins like defensing, hepcidin and chemerin in females of elder age suffering from iron deficiency anemia. Methodology: In this research work, we used the samples of blood of 20 healthy females (55.0±7.0 years of average age) and 20 females suffering from Iron Deficiency Anemia (58.0±6.0 of average age). This research work was carried out in DHQ Hospital Rajanpur from November 2018 to August 2020. Results: In this current research work, levels of CRP (C - Reactive Protein) (P<0.010), TNF-α (Tumor Necrosis Factor-α) (P<0.050) and IL-6 (Interleukin-6) (P<0.050) were much high in the group of Iron Deficiency Anemia when we compared them with the members of healthy group. The levels of hepcidin (P<0.0010), chemerin (P<0.050) and defensin levels (P<0.050) were also much high in the patients as compared to the healthy groups. Conclusion: We discovered that there is occurrence of inflammatory changes in the females of elder age suffering from iron deficiency anemia. Besides the levels of pro-inflammatory cytokine (CRP, IL-6 and TNF-α), the levels of anti-microbial proteins (hepcidin, chemerin and defensin) were also much higher in the females of elder age suffering from Iron Deficiency Anemia because of the presence of different inflammatory alterations. Keywords: Anti-Microbial, Anemia, Tumor Necrosis Factor-Α, C - Reactive Protein, Cytokines, Iron Deficiency, Inflammatory.