::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

GAIT AND FUNCTIONAL MOBILITY IN MULTIPLE SCLEROSIS

AUTHORS:

Dr Muhammad Farooq Umer Chhena, Dr Ansar Abbas, Dr Musarat Shaheen

ABSTRACT:

Introduction: Gait is a complicated process involving coordination of multiple systems within the body (e.g., central nervous, musculoskeletal, and cardiovascular system). Objectives: The main objective of the study is to analyse the gait and functional mobility in multiple sclerosis. Material and methods: This descriptive study was conducted in Islamic International Medical College Rawalpindi during June 2019 December 2019. The data was collected from 17 patients. Eligibility criteria included ages 18–70 years, level of neurologic disability as measured by the Expanded Disability Status Scale (EDSS) score from 1.0 to 6.5, and the ability to independently walk (with or without an assistive device) for at least 20 m. Results: The data was collected from 17 patients. Stimulation was well-tolerated across participants and with side effects of itching, tingling, and head pain. No side effect reached an intensity level of >7 (rated on a 0- to 10-point scale) for any participant, and all side effects resolved at the end of the stimulation period. All participants completed the 20-min aerobic exercise maintaining the targeted moderate level. The average HR during the session was 110.9 ± 4.0 beats/min. There were no significant main effects of the intervention, as well as of the time and time × intervention interactions for gait speed and TUG time, respectively. These findings indicate no immediate effect on walking and functional mobility performance with either tDCS paired with aerobic exercise or aerobic exercise alone. Conclusion: It is concluded that ait variability is elevated in individuals with MS and potentially clinically significant. Additionally, a number of factors have been linked to gait variability in MS, including disability level, assistive device use, dual-task performance, and fatigue.