::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

SERUM MAGNESIUM AND VITAMIN D LEVELS AS INDICATORS OF ASTHMA SEVERITY

AUTHORS:

Dr Zain ul Hassan,Dr Anum Amjad,Dr Abdul Hadi

ABSTRACT:

Background The concentration of vitamin D in the blood is affected by the magnesium serum level that affects immunity of the human body. The pathogenesis of asthma is dependent on the concentration of magnesium and vitamin D. Asthma is not common in adults, but a deficiency of vitamin D and serum magnesium level is prominent is asthmatic patients and lack of these levels causes severe asthma attacks, respiratory infection and poor response to bronchodilators in case of severe exacerbation. Objective The main purpose of this article is to check the deficiencies of vitamin D and serum magnesium level in the blood and relate these with severity of asthma. Material and Methods A cross sectional case control study, which includes 60% asthmatic patients and 60% healthy volunteers and then clinical and systemic examination have been done and serum magnesium level, 25- hydroxycholecalciferol [25(OH) D] and Vitamin D levels are measured. Results Severe hypomagnesaemia and deficiency of Vitamin D is observed that causes severe asthmatic attacks. But calcium levels remain constant. Conclusion The deficiency of Vitamin D and lack of Magnesium level is highly observed in asthmatic patients. And with the deficiency of one or both can cause severe breathing problems, severe exacerbation of respiratory distress and asthma severity. Serum 25(OH) D levels and magnesium concentration are highly important markers of Asthma severity.