- CODEN : IAJPBB
- issn 2349-7750
TITLE:
ASSOCIATION OF INTRAHEPATIC CHOLESTASIS OF PREGNANCY (ICP) WITH ADVERSE FETAL OUTCOME
AUTHORS:
Dr. Komal Mushtaq, Dr.Arif Hussain, Dr Nasar Shah
ABSTRACT:
Objective: This study aimed to observe the relation of pregnancy intraheptic cholestasis and its adverse fatal consequences. The study design of this research is Cohort study. Methodology: This Study was conducted in Holy Family Hospital Rawalpindi ;In this study a specific incuslion and excluion criteria was defined and then accordig to inclusive criteria 110 subjects including having the second trimester. These 110 patients divided into two groups both having 55 patients according to their LFTs. For example group A included those patients who had deranged LFTs and group B included those who had normal LFTs. Observation till thrid trimester continued and adverse outcomes like meconium stained liqour and preterm labor were the parameters observed and compared between both groups. Results: Mean age of 110 subjects was 27.8± 4.5years. Out of all selected subjects 45% had more than one pregnancies and 30% had one pregnency while 24.5% were prim gravida. In group A 27 patients had more than one pregnancy, 14 had one pregnancy and 14 were prim gravida. In group B 23 patients had more than one pregnancy, 19 had one pregnancy and 13 were prim gravida. In group A mean Bilirubin was 2.3 mg/dL, ALP was 1039.9U/L, AST was 132.1 U/L, ALT was 132.7 U/L. Whereas in group B mean Bilirubin was 0.93 mg/dL, ALP was 622.7 U/L, AST was 28.5 U/L, ALT was 28.7 U/L. In group A 32 subjects had preterm labor while 35 had meconium stained liqour whereas in grpup B, 7 subjects had preterm labor while 7 had meconium stained liqour. Conclusion: As compared to normal pregnancy ICP is a condition that can cause meconium staining liqour and preterm labor and affect fetal outcomes. However, there is no relation between parity and age with adverse fatal ountcomes. Keywords: Preterm labor, Meconium, Liver function tests, liquor, intraheptic cholestasis
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