::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

FACTORS INFLUENCING THE OUTCOME OF HOSPITALIZATION AMONG PATIENTS WITH LIVER CIRRHOSIS

AUTHORS:

Dr Manahil Masood, Dr Shabana Shaheen, Dr Samreen Javed

ABSTRACT:

Objectives: To identify factors influencing the outcome of hospitalized patients with liver cirrhosis. Methods: Data of patients with cirrhosis aged> 12 years who were hospitalized were included after informed consent were collected using the method of purposive sampling. There was a hospitalization score for "death" and "non-death". Statistical analysis was performed with SPSS version 25. Two-dimensional analysis and binary logistic regression were performed to determine the influence of various prognostic factors such as gender, age, diabetes history, liver cirrhosis etiology, presence of hepatic encephalopathy at presentation, presence of the upper gastrointestinal tract tracheobronchial bleeding and aspiration on the likelihood of death in patients with cirrhosis of the liver. Results: Out of 1,304 patients, 15.7% died during hospitalization. The mean age of the deceased was 58.08 + 14.49 years. Two-dimensional analysis suggested that mortality was significantly higher in the group of patients with hepatic encephalopathy at presentation (p <0.01), without upper gastrointestinal bleeding (p <0.01). It was not significantly different between male / female genders (p = 0.504), diabetic / non-diabetic groups (p = 0.652), and viral / non-viral etiology of cirrhosis (p = 0.918). Binary logistic regression revealed that patients with tracheobronchial aspiration were 12.3 times more likely to die than patients without tracheobronchial aspiration. Similarly, in patients with hepatic encephalopathy, the likelihood of death was 7.862 times greater than in patients without hepatic encephalopathy. Conclusion: Hospital mortality among patients with cirrhosis was high. Age, sex, history of diabetes, viral etiology of cirrhosis did not significantly affect the mortality of these patients. Patients who developed hepatic encephalopathy and who experienced tracheobronchial aspiration during hospitalization had a higher risk of death. Excellence in treating hepatic encephalopathy and preventing aspiration can effectively reduce the mortality rate of patients with cirrhosis in our hospitals. Keywords: liver cirrhosis, hospitalization result, pulmonary aspiration, age groups, SPSS.