::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

HELICOBACTER PYLORI INFECTION IN PATIENTS WITH HCV-ASSOCIATED LIVER CIRRHOSIS AND ITS ASSOCIATION WITH THE SEVERITY OF PORTAL HYPERTENSIVE GASTROPATHY

AUTHORS:

Dr Momal Jaleel Khan, Dr Sara Sahar, Dr Nida E Zahra

ABSTRACT:

Aim of the study: Helicobacter pylori infection is a serious health problem as approximately 50% of all people in the world are infected with Helicobacter pylori. Portal hypertensive gastropathy (PHG), a term used to describe the endoscopic appearance of the gastric mucosa with a characteristic mosaic-like pattern with or without red spots, is a common symptom in patients with portal hypertension. The role of H. pylori infection in the severity of Portal hypertensive gastropathy is controversial, so we are trying to prove whether there is any role for H. pylori infection and the severity of PHG. Place and Duration: In the Medicine Unit-II of Sheikh Zayed Hospital, Rahim Yar Khan for one-year duration from September 2019 to September 2020. Patients and Methods: Eighty consecutive patients with HCV-associated cirrhosis were enrolled in the study. The diagnosis of H. pylori infection was made by detecting H. pylori Ag in the feces by ELISA. 80 consecutive patients with HCV-related cirrhosis were enrolled in the study. All patients underwent upper gastrointestinal endoscopy and an ELISA test for H. pylori Ag in the stool. The diagnosis and severity of portal hypertensive gastropathy (PHG) was assessed during endoscopy. Child-Pugh and MELD scores were calculated to assess the severity of cirrhosis. Results: H. pylori infection was reported in 46 patients, with the overall frequency of 57.5%. PHG was found in 57 patients (71.25%); Of these, 36 (63.15%) had mild and 21 (36.15%) severe PHG. H. pylori was more common in patients with PHG than without PHG (57.5% vs 42.5%; p <0.001). There was no significant association between H. pylori infection and the severity of cirrhosis according to Child-Pugh (p = 0.383) and MELD (p = 0.666). Conclusion: Our results showed a significant association between H. pylori infection and the incidence and severity of PHG in patients with HCV-associated cirrhosis. However, the severity of cirrhosis in itself did not correlate with H. pylori or the severity of PHG. Thus, eradication of H. pylori may be beneficial for improving PHG. Key words: portal hypertensive gastropathy, Helicobacter pylori, liver cirrhosis.