Dr Faiza Azam,Dr Muhammad Ahmad,Dr Kaneez Fatima
Diabetes mellitus (DM) has a critical role in the development and progression of chronic liver disease (CLD) of different etiologies. Both DM and CLD are strongly connected through worse clinical outcomes which reduced the 40% survival rate in 5 years. The identification of an effective treatment strategy becomes a challenge to manage diabetic patients with liver disease particularly with decompensated cirrhosis. As we have a lack of knowledge of clinical guidelines as well as the medical complexity of this patient folk. We review the epidemiology and pathophysiology of both CLD and DM, insulin resistance impact on the progression of CLD, and practical challenges in diagnosis and monitoring of DM. finally, we discussed the few evidence on pharmacological therapy such as anti-hyperglycemic therapies with liver disease-related clinical outcomes.