- CODEN : IAJPBB
- issn 2349-7750
TITLE:
PREDICTING THE RISK OF HIGH BLOOD PRESSURE AND CARDIOVASCULAR DISEASE AMONG PAKISTANI POPULATION
AUTHORS:
Dr. Muhammad Umar, Dr. Muhammad Usama Bilal, Dr. Arsalan Shabeer
ABSTRACT:
Background: It has been found that aging is associated with various types of health complications. Therefore, this study was designed to evaluate plasma Paraoxonase (PON), nitric oxide (NO), total antioxidant activity (TAA), lipid peroxidation, and serum uric acid levels in blood samples of people of different age groups and to determine their relationship in predicting high blood pressure and the risk of cardiovascular disease with aging. Place and Duration: In the Medicine and Biochemistry department of Services Institute of Medical Sciences and Hospital for one-year duration from July 2019 to July 2020. Methods: Markers of antioxidant reserves (PON, TAA, and uric acid), lipid peroxidation and endothelial dysfunction were assessed in selected 120 healthy subjects using standard methods. Out of 120 subjects, 80 people were divided into two groups: group I (40-55 years old) and group II (≥56 years old) and statistically compared with 40 younger controls (20-30 years old). Results: People from groups I and II showed a significant decrease in plasma PON and NO levels compared to healthy controls, while the levels of lipid hydroperoxide (LHP) and malondialdehyde erythrocytes (MDA) were significantly increased (P <0.05) in group I and II. themes. However, the plasma levels of TAA and uric acid changed significantly (P <0.05) only in group II. Moreover, PON levels were inversely correlated with endothelial dysfunction, lipid peroxidation and uric acid, and positively associated with TAA. Conclusions: These results reflect the importance of plasma paraoxonase assessment as an excellent marker along with NO in the early prediction of the risk of hypertension and related cardiovascular complications in the elderly. Therefore, as you age, you need to strengthen your body's antioxidant defense system to avoid future complications. Key words: lipid hydroperoxide, paraoxonase, uric acid, nitric oxide, total antioxidant activity
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NLM ID:101711216 [Serial]
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cosmos Impact Factor:4.153
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