::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

TO COMPARE THE EFFECTIVENESS AND SAFETY OF NIFEDIPINE WITH BETA-SYMPATHOMIMETICS FOR SUPPRESSION OF PRETERM LABOUR

AUTHORS:

Dr Haroon Nawaz, Dr Afreen Fatima, Dr, Sana Ashfaq

ABSTRACT:

Objective: Preterm labour is defined as onset of labour after 24 weeks and before 37 completed weeks of gestation. About 13 million preterm births occur worldwide annually. Aim of the study was to compare the effectiveness and safety of Nifedipine with beta-sympathomimetic for suppression of preterm labour. Study Design: Quasi-Experimental study. Place and Duration of Study: This study was conducted at the Obstetrics and Gynecology Department of Jinnah Hospital Lahore for the duration of one year from July, 2019 to June, 2020. Materials and Methods: A total of 120 admitted pregnant women in preterm labor were studied. Patients were divided into two groups of 60 each. The patients presenting with regular painful uterine contractions at frequent intervals and with appreciable cervical change, at gestation > 24weeks or < 37 weeks were admitted for tocolysis. Two groups were formed by using random numbers table. Group A was given Nifedipine and Group B was given Beta-sympathomimetic drug i.e. Terbutaline. All relevant information was written on proforma. Results: During study period, 120 patients were enrolled. 60 patients were randomized to Nifedipine and 60 to Beta sympathomimetic treatment. The age distribution, gravidity and gestational age were same in both groups. Tocolysis was successful in 93 % of patients in Nifedipine group and 67 % of patients in Beta sympathomimetic group. It failed in 7% and 33% in Nifedipine and Beta sympathomimetic groups respectively. The mean gestational age achieved at delivery was 32.67 ± 2.248 and 32.43 ± 2.473 in Nifedipine group and Beta sympathomimetic group respectively. Nifedipine caused effective tocolysis in 83% patients within 24 hours whereas Beta sympathomimetic caused it in only 56% patients within 24 hours. Hypotension was the commonest side effect seen in 17% of patients in Nifedipine group and 43% in Beta sympathomimetic group. Tachycardia was observed in 70% of the patients and vomiting was observed in 12% of patients in Beta sympathomimetic group. Conclusion: Nifedipine is more efficacious and safe as compared to Beta sympathomimetic in suppression of preterm labour with lesser side effects. Key Words: Preterm labour, Prematurity, Cervical incompetence, Tocolysis.