Dr Jamil Alam, Dr Shoaib Hameed Lone, Dr Shujaat Hussain
Objectives: The aim of our study was to define the occurrence of Diabetes Mellitus (DM) in Hepatitis C Virus cirrhotic patients and relationship of hepatic encephalopathy in Hepatitis C Virus Cirrhotic patients with diabetes mellitus. Study design: A cross sectional study. Place and Duration: This Analytic cross-sectional study was conducted in Community Medicine Department of Holy Family hospital, Rawalpindi for the duration of one year starting from September 2019 to August 2020. Methodology: The sample size of 100 patients was calculated with 95% confidence level, 9.5% margin of error and taking expected percentage of diabetes i.e. 33.5% in patients of Hepatitis C Virus liver cirrhosis. Non-Probability purposive sampling technique was used to select either gender patients with Hepatitis C Virus cirrhosis and ages ranging from 16 to 60 years. Using non-probability purposive sampling we selected 100 patients with Hepatitis C Virus associated cirrhosis. In our study presence of hepatic encephalopathy was clinically determined and selected patients were stratified as diabetic and non-diabetic according to ADA criteria. The Frequency and percentage of hepatic encephalopathy is use to determine the association of diabetes and their odd ratios. P-value 0.05 was considered significant. Results: From all selected patients (100) there were 34 females and 66 males. According to age Mean±SD was as 44.43±10.16 years. Among these there were 34 patients of Hepatitis C Virus cirrhosis who were diabetic positive. There were 31 patients who has Hepatic encephalopathy with 91.2% of the diabetic cases 48 patients who has Hepatic encephalopathy with non-diabetic patients with odd ratio of 3.876. P value was 0.016. Conclusion: Hepatic encephalopathy (HE) is significantly associated with diabetes mellitus. Now Hepatitis C Virus patients should be screened for glycemic level and diabetes to prevent development of hepatic encephalopathy. Key Words: Hepatic Encephalopathy (HE), Diabetes Mellitus (DM), Neuropsychometric Test, West Heaven Criteria, Hepatitis C Virus (HCV).