::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

A CROSS SECTIONAL STUDY ON SPONTANEOUS BACTERIAL PERITONITIS IN LIVER CIRRHOSIS

AUTHORS:

Dr Aurangzeb Khan, Dr Saba Iqbal, Dr Munaza Khattak

ABSTRACT:

Objective: To determine the frequency of spontaneous bacterial peritonitis (SBP) in patients with liver cirrhosis. Material and Methods: This was a cross sectional study, carried out at Saidu Teaching Hospital, Swat and the duration of this study was from January 2020 to May 2020. In this study the patients of liver cirrhosis of either gender and with age range of 20 to 70 years were included. The diagnosis of liver cirrhosis was made on clinical examination and on USG abdomen revealing coarse echo texture with or without splenomegaly. The patients with alcoholism and hepatocellular carcinoma were rule out. Spontaneous bacterial peritonitis was labelled when Serum ascitic albumin gradient >1.1, total leukocyte count >500/ml and neutrophil count > 250/ml. Results: In this study there were 100 patients of liver cirrhosis and out of these 64 (64%) were males and 36 (36%) females. The mean age of the patients was 51.34±9.62 years. There were 67 (67%) in Child Pugh class C. Spontaneous bacterial peritonitis was seen in 32 (32%) of the patients. There was no significant difference in terms of gender and age with p values of 0.97 and 0.95 respectively. However, spontaneous bacterial peritonitis was significantly high in patients that had child Pugh class C where it was seen in 25 (37.21%) of patients as compared to 7 (21.21%) of patients in class B with p value of 0.04. Conclusion: Spontaneous bacterial peritonitis is seen in almost every 3rd patient of liver cirrhosis and is seen significantly high in patients that had Child Pugh class C. KEYWORDS: Splenomegaly, Liver Cirrhosis, Spontaneous Bacterial Peritonitis, Neutrophil, Carcinoma