Dr.Tehreem qayyum, Dr. Surakshya Ghimire, Omyya Baloch
A worldwide chronic autoimmune disorder, systemic lupus erythematosus terribly affects each organ and tissue. Disease development and activity may be influenced by a few factors including environmental triggers, hormonal abnormalities, and genetic variation. The heterogeneity is existed in the clinical pattern and between the patients which fluctuate treatment over time in every patient. The complex pathology of SLE includes the immune complexes, abrupt regulation of various cytokines, and disturbance in the clearance of nucleic acid followed by cell death. The aim of treatment is to achieve a lower degree of activity through the immunomodulators, immunosuppression, and stave off the organ from the harmful effect of active lupus. Diminish the secondary diseases and treatment to overcome accelerating atherosclerosis and decrease the major reasons that lead to death. Commence the treatment at an early stage as soon as possible after the diagnosis is very essential to bring back the patient to normal life.