Dr Haseeb Ahmed Khan,Dr Muhammad Adeel Ahmed,Dr Fawad Afzal Abbasi
The neuropsychiatric systemic lupus erythematosus (NPSLE) is a multifactorial disorder with worse outcomes on a patient’s life. Disease have heterogeneous and uncommon neuropsychiatric (NP) manifestations including the central and peripheral nervous system. Clinical presentation is challenging due to deficits of standard for proper management. The clinical manifestation of non-SLE does not differ with NP symptoms. Subsequently, individualized therapeutic strategies based on the severity of symptoms were applied. Symptomatic therapy is an adequate method to treat mild NP patients while the same method is ineffective to treat the patient with severe signs of NPSEL. MRI with other different techniques can be used to identify the NP and SEL. Further, the article is a review of the diagnosis, current and future management of NPSEL.