::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

CYSTATIN C LEVELS IN MIDDLE-AGED PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROME

AUTHORS:

Dr Muhammad Nawaz,Dr Muhammad Yousuf Nawaz,Dr Ghulam Mujtaba

ABSTRACT:

Obstructive sleep apnea syndrome (OSAS) relates to the systemic inflammation and higher risk of cardiovascular and chronic kidney disease. Cystatin C (Cyst C) is a unique biological marker of xboth latent renal damage and cardiovascular disease. The purpose of this research was to measure levels of serum of Cyst C, in addition to IL-8 and CRP, in unhealthy OSAS patients. Methods used for this study includes 82 individuals examined with polysomnography for OSAS symptoms without known comorbidities were recruited tentatively. The results showed that as per to apnea hypopnea index (AHI) subjects were partitioned in two groups: one was OSAS group (AHI > 5/hour, n=61) and other one was controls (AHI < 5/hour, n=21), which were age- and BMI-matched. Higher Cyst C levels was seen in OSAS group than in control group (1175.12 +/- 350.30 versus 935.60 +/- 242.83 ng/mL, resp.; p= 0.017) however the levels of IL-8 and CRP very almost the same. Cyst V levels was found to have a positive correlation with the respiratory disturbance index (r = 0.239, p = 0038) and the percentage rate of oxygen<89.9% (r = 0.291, p = 0.02), and a negative correlation with the oxygen saturation while sleeping (r = -0.292, p = 0.013). The only independent predictor for Cyst C levels was RDI, when the age and BMI were adjusted (β = 0.256, p = 0.038). The result concluded that Cyst C levels are higher in the OSAS patients without comorbidities, proposing and expanded renal and cardiovascular disease hazard.