::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

EVALUATION OF THE AMOUNTS OF RECOGNITION OF mAlb, α1-MG AND NAG IN TIMELY DIABETICNEPHROPATHY

AUTHORS:

Dr Asif Hassan, Dr M Waqas Saleem, Dr Hafiz Muhammad Usman Tariq

ABSTRACT:

Objective: The objective of this work and study is to evaluate the amounts of combined recognition of urinary mAlb (Urinary Micro Albumin), α1-MG (α1‑Microglobulin) and NAG (N-acetyl-β-D-glucos aminidase) in timely diagnosis of DN (Diabetic Nephropathy). Methodology: We compared the detection outcome of all the 3 groups and then we statistically analyzed the available information. Total 94 patients with early diabetic nephropathy who got admission in Lahore General Hospital, Lahore from December 2017 to December 2018, were the participant in DN group. Moreover, total 67 patients suffering from diabetes who got admission in the similar period were included in the diabetes group and we selected the 64 healthy persons in the control group. We detected the NAG, urinary mAlb and α1-MG of the all 3 groups. Furthermore, we divided the patients into a satisfactory blood glucose control group& an adverse blood glucose control group in accordance with the control condition of blood glucose of the patients. Results: The values of detection indicator satisfactory blood glucose control group were low as compared to adverse blood glucose control group. The levels of NAG, urinary mAlb and α1-MG of group of DN were much high as compared to the patients of control and diabetes group. The differences were statistical significance with P value <0.050. These differences were also statistically significant with P value of <0.050. The rate of positivity of the combined detection of levels of NAG, mAlb and α1-MG was 90.20%, which was very high as compared to of single indicator with P value of < 0.050. Conclusion: Combined recognition of the NAG, urinary mAlb and α1-MG is much sensitive in the identification of the initial damages in renal function among the patients suffering from DN. Keywords: mAlb, α1-MG, diabetic nephropathy, controls, DN, NAG, indicator, statistically, analysis.