Dr Ifrah Fatima Zafar, Dr Lubna Asgher, Dr Muhammad Umar Farooq
The uncontrolled cell growth, knows as carcinogenesis, following the activation of oncogenes along with deactivation of cancer suppression genes. Down-regulation of cell adhesion receptors that are important for the tissue-specific, attachment of cell-to-cell just as up-regulation of receptors that improve motility, is required in metastasis. The epigenetic changes, including modification of histone, methylation and hydro methylation of DNA, help to modify these characteristics. Focuses for these changes incorporate signaling pathways, which control apoptosis and autophagy, just as micro-RNA. We say that the normal predisposed cells, converts to cancerous progenitor cell, which, after growing, go through an epithelial-mesenchymal conversion. This cycle, which is commonly under the control of epigenetic changes, can make a metastatic type of both progenitor and full-fledged cancer cells, after which metastasis to a removed place may happen. Potential therapeutic avenues have been provided by the recognition of epigenetic regulatory process. The action of traditional therapeutics was potentiated more specifically due to these epigenetic drugs. These epigenetic drugs inhibit the formation and development of cancer progenitor cells. Hence, it represses the recurrence of cancer. Receiving epigenetic adjustment as another sign of malignancy is an intelligent and vital advance that will additionally empower the improvement of novel epigenetic biomarkers and therapeutics.