Dr Maimoona Siddiq, Dr Erum Behroz, Dr Junaid Shakeel
Objective: The aim of this study is to access, evaluate and make comparison of levels of salivary EGF in individuals having medical conditions like oral gingivitis and advanced periodontitis along with patients with healthy oral cavity conditions. Study Design: This was a Comparative Study Place and Duration of Study: This study was conducted in orthodontic department of Jinnah Sindh Medical University Karachi, for the duration of six months, from January 2020 to July 2020. Materials and Methods: The samples of saliva that were unstipulated gathered from mouth of patients having oral conditions like advanced periodontitis, gingivitis and from individuals with healthy oral conditions. The clinical parameters that were measured during this case study were bleeding on probing (BOP), plaque index (PI), clinical attachment level (CAL) and probing pocket depth (PPD) with the help of a Williams probe. EGF levels were recorded by using enzyme-linked immune sorbent assay (ELISA). For data analysis and evaluation, One- way ANOVA was used. Results: In Individuals with healthy oral conditions, EGF levels were noteworthy higher (99.00) as compared to patients suffering from gingivitis (62.49). EGF value was still higher in patients with gingivitis as compared to patients with advanced stage periodontitis (37.12) (P<0.001). Conclusion: The decline in mean levels of EGF in individuals suffering from periodontal disease may be due to periodontal diseases. Key Words: Gingivitis; Epidermal Growth Factor; Salivary Proteins, Pep-tides.