::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

INTERACTION OF ANTIMICROBIAL PEPTIDES AS AN ALTERNATIVE TREATMENT OF TUBERCULOSIS

AUTHORS:

Dr. Muhammad Haseeb, Dr. Sajid Abbas, Dr. Muhammad Hammad Yaqub

ABSTRACT:

Introduction: Tuberculosis (TB) is still one of the most deadly communicable diseases worldwide. In 2013, an estimated 9 million people developed TB and 1.5 million people died from TB. The global trend is a decrease of incidence, prevalence, and mortality. Objectives of the study: The basic aim of the study is to analyze the interaction of antimicrobial peptides as an alternative treatment of tuberculosis. Methodology of the study: This cross sectional study was conducted at Allied Hospital Faisalabad during July 2019 to December 2019. The patients of both genders were selected for this study. Those patients who suffered from TB from last one year was included in this study. In this analyzes we compare the different drugs of TB which are available in the market as compared to antimicrobial peptides. Results: In general the three methods led to the same results. Linde et al. and other groups assayed the antimycobacterial activity by the BACTEC radio-metric method, which detected growth of mycobacteria by measurement of CO2 released as a consequence of bacterial catabolism. Conclusion: It is concluded that Many AMPs have good or moderate activities against mycobacteria, however, in general the activities are lower as compared to the activities found against other Gram-negative or Gram-positive bacteria.