Dr Humaira Ilyas, Dr Saira Sundus,Dr Mamuna Ayub
Milk is a vital part of the diet of every mammal but this leads 70% of the World's population to suffer lactose intolerance. In lactose intolerance LPH (Lactase-phlorizin hydrolase) level is low in the intestine which is not sufficient to break lactose into a simpler form, β -galactosidase which is present on the upper surface of microvilli of the small intestine is also responsible for the hydrolysis of lactose. Lactose is a disaccharide that needs to be hydrolyzed in the presence of lactase enzyme otherwise it may lead to severe clinical conditions categorized by flatulence, abdominal distension, Crohn's, ulcerative diseases, and diarrhea. It is due to recessive autosomal gene and varies from population-to-population Lactose intolerance has four types; primary, secondary, developmental, and cognitive lactose intolerance. Lactose malabsorption leads to lactose intolerance as the undigested lactose present in the gastrointestinal tract cause severity. Lactose intolerance can be diagnosed by testing but among all of them, genetic tests and human blood tests are consistent and economical. For lactose intolerance patients therapeutically interventions and probiotic foods articulating β-galactosidase were recommended because it hydrolyzed the indigestible lactose to digestible lactic acid. Additionally, supplemented plant-based milk can be used as a substitute of milk which can fulfill the daily recommended allowance of calcium and vitamins. This article aims to provide coherent knowledge on lactose intolerance, lactose malabsorption, and to articulate the supplementary diet for lactose-intolerance patients from the latent use of probiotic strains.