Dr Madikh Hameed,Dr Muhammad Umer Iftikhar,Dr Hafiza Maryam Liaqat.
SARS-CoV-2 and COVID-19 both are the types of coronaviruses that firstly outbreak in the seafood market of China, in Wuhan. Epidemiological and clinical characteristics have revealed their morphology, pathology, and transmission. SARS-CoV-2 shows a similarity of about 80% with SARS-CoV and 50% with MERS-CoV. ACE2 (Angiotensin-converting enzyme 2) is the receptor of SARS-CoV-2. By comparing both it has been observed that SARS-CoV-2 is the most severe strain with high mortality rate than COVID-19 although the mode of transmission of COVID-19 is much quicker its pathophysiological impact is still limited. Many cases of COVID-19 infected neonatal babies and asymptomatic children were reported. Mothers suffering from COVID-19 could have complications during giving birth as there were chances of vertical transmission of the virus to the new-borns. Children with gastrointestinal symptoms may suffer from severe disorders and illnesses. Laboratory Reports of COVID-19 infected children have resulted in a decreased level of CD8+, and CD4+ T-cells and higher Lactate dehydrogenase (LDH). This article focusing on future primary strategies and recommendations to overcome the percentage of COVID-19 infected children.