::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

ELUCIDATE THE CLINICAL EFFECTS OF BLOOD TESTOSTERONE CONCENTRATION ON CAVI IN WOMEN WITH DM-TYPE 2 DISEASE

AUTHORS:

Nafia Shahid, Iram Jaffri, Afifa Siddiq

ABSTRACT:

Background: Data seeing testosterone as a critical danger factor of cardiovascular illness (CVD) in female patients with type 2 diabetes mellitus (DM) is restricted. Notwithstanding, some clinical examinations revealed the significance of cardio-lower leg vascular list (CAVI) as a novel physiological marker of blood vessel work in sort 2 DM. This cross-sectional investigation expected to explain the clinical impacts of blood testosterone focus on CAVI in female patients with type 2 DM. Methods: An aggregate of 238 postmenopausal patients incorporating 97 with a background marked by CVD with type 2 DM (age (mean ± standard deviation (SD)), 73 ± 9 years) were enlisted. Our current research was conducted at Services Hospital, Lahore from May 2019 to April 2020. CAVI was estimated by the standard method, and serum all out testosterone fixation (T-T) was additionally estimated as a testosterone level marker in vivo. The connection among CAVI and T-T was assessed. Results: CAVI is fundamentally higher (CVD versus non-CVD: 10.2 ± 1.2 versus 9.2 ± 1.0, P < 0.001), and log-T-T altogether lower (CVD versus non-CVD: 1.2 ± 0.2 ng/dL versus 1.5 ± 0.2 ng/dL, P < 0.001) in patients with CVD than those without CVD. CAVI was fundamentally adversely associated with log-T-T (r = - 0.41; P < 0.001). Besides, various relapse examination demonstrated that CVD (β = 0.23; P < 0.001) and log-T-T (β = - 0.18; P < 0.01) were chosen as free subordinate factors for CAVI. Conclusion: This examination demonstrated that T-T was autonomously conversely connected with CAVI, showing that low testosterone fixation is an extensive danger factor for the movement of blood vessel brokenness in female patients with type 2 DM. Keywords: Clinical Effects, Blood Testosterone Concentration, Cavi, DM-Type 2 Disease