::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

THE POSTPRANDIAL EFFECT OF PRE MEAL BAR AND DIETARY FIBRE IN TYPE 2 DIABETES MELLITUS

AUTHORS:

Dr Manzoor Hussain, Dr. Sundas Mahmood Dar, Dr Marwah Mahmood

ABSTRACT:

Aim: Protein preload improves postprandial glycaemia by animating discharge of insulin and incretion hormones. Notwithstanding, it requires a huge portion of protein to produce a critical impact. The current examination was completed to explore the postprandial glucose-bringing down impact of a primal protein-enhanced, dietary fiber-strengthened bar (PFB), which contains moderate measures of protein, in people with type 2 diabetes mellitus or on the other hand ordinary glucose resilience (NGT). Materials and Methods: The members (15 sort 2 diabetes mellitus and 15 NGT) were haphazardly appointed to either a premeal or Postmeal PFB gathering and went through two blended feast resistance tests, multi week separated backward request. Our current research was conducted at Jinnah Hospital, Lahore from June 2019 to May 2020. Plasma levels of glucose, insulin, glucagon-like peptide-1 and glucose-subordinate insulinotropic polypeptide were estimated. Results: In mixed-feeding resistance testing, the gradual range below the 0 to 190 min elbow of plasma glucose levels was lower with premeal PFB than with Postmeal PFB in type 2 diabetes mellitus (15,724 - 1,320 mg min/dL vs. 19,643 - 1,368 mg min/dL; P = 0.0003) and NGT members (3,944 - 416 mg min/dL vs. 4,828 - 522 mg min/dL; P = 0.0297). In the type 2 DM members, insulinogenous list and stable elbow zone from 0 to 180 min of plasma, all glucagon-like peptide-1 levels were higher with pre-meal PFB than with post-meal PFB, but not in the NGT members. There was no distinction in the levels of tropical polypeptides of postprandial glucose-subordinate insulin between pre-meal and post-meal BFP in either gathering. Conclusion: Acute organization of premeal PFB diminished postprandial glucose trip in both sort 2 diabetes mellitus and NGT members. In the sort 2 diabetes mellitus members, pre-meal PFB increased the beginning stage insulin discharge, perhaps through improving glucagon-like peptide-1 discharge. Keywords: Postprandial, Hypoglycemic Effect, Pre-Meal Bar Enriched, Protein, Dietary Fiber, DM type-2.