Dr Haider Ali,Dr Munibah Mughal,Dr Usman Akhtar
Migraine is one of the causes of disability on the Earth and a socioeconomic burden  . Due to physical activity, migraine pain becomes worse. It may last from 4 to 70 hours. Pharmacological treatment is based on the characteristics of the intensity of the migraine attack. Pharmacodynamics and Pharmacokinetic is necessary for migraine therapy. Migraine disorder has a poor relation to sleep. Sleep plays a therapeutic role in the discontinuing of migraines. Patients continuously report poor sleep before the migraine attacks and during migraine attacks. Migraine is a neurological disorder that is experienced by 10% of the total population. The current review will point up the contemporary aspects of migraine pathophysiology and comprehend the migraine state's working, and the brain is responsible for them. It was evident that neuromodulator strategies require further investigations to confirm their viability in headache. New medicines are quickly opening up for patients. Many facts of migraine pathophysiology are still unclear. Research has been directed to understand all the phrases included in the Migraine attack. According to the Global Disease Study, researchers estimated that more than 1 billion people were suffering from this migraine disease . It becomes the most neurological disorder. It is the cause of disability in women between the age of 15 and 49 years . Despite the arrival of new drugs, most patients do not experience relief and relaxation. Most of them are unwilling to use pharmacological treatments. Neuromodulation can define as a drug that restrains the transmission of impulse nerve, but it is not the actual transmission . According to the terminology, many interventional techniques are classified as neuromodulatory. For preventive migraine treatment, non-invasive and invasive neurostimulation methods have been proposed. This technology comes out as a safe alternative for pharmacological therapy of migraines, especially for sensitive patients like pregnant and adolescents . At the same time, non-pharmacological neuromodulatory approaches prove cost-effective.