::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

CROSS EXAMINE THE PATTERN OF ASSOCIATION BIO-CHEMICAL FACTORS AND BONE MARROW INFILTRATION CONNECTION IN PATIENTS PRESENT WITH NON- HODGKIN LYMPHONA

AUTHORS:

Nida Esa, Rabia Nazir, Muhammad Rashid

ABSTRACT:

Objectives: The aim of this work is to cross-examine the pattern of association of bone marrow in the patients present with NHL (Non-Hodgkin’s Lymphoma) and to associate the pattern of β2-m (β2 microglobulin) & LD2 (Lactate Dehydrogenase-2) levels of these present patients. Methodology: The determination of the correlation coefficients carried out with the utilization of the Pearson’s correlation coefficient. We made the estimations before the establishment of chemotherapy. This transverse research work carried out for a period of complete two years in Sir Ganga Ram Hospital, Lahore. This research work carried out on fifty patients irrespective of gender and age separated into 2 groups i.e. Group-A containing twenty healthy controls whereas Group-B consisting thirty patients of non-Hodgkin lymphoma with the infiltration of bone marrow. We performed bilateraltrephine biopsy of bone marrow to evaluate the patterns of infiltration of bone marrow. The determination of serum β2-m andLD-2 levels in already identified thirty patients of non-Hodgkin lymphoma. We compared these values with twenty healthy gender and age match controls. Results: The markers of serology displayed negative correlation (-0.2350 for β2-m & -0.1330 for LD-2) with disease spread and association patterns in the patients of NHL. There was significant rise in the levels of β2-m and LD-2 (P-value < 0.050) in the patients of NHL with the advancement of disease as compared to the healthy controls. Conclusion: With the examination of patterns of association of bone marrow in the patients of NHL possible instruction about the conduct and prognosis protocols can be taken as the markers of serology levels associate with the disease spread an involvement pattern in NHL patients. KEY WORDS: Correlation, NHL, bone marrow, significant, association, determination, chemotherapy, serum.