::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

CONNECTION BETWEEN HYPERTENSION AND HIGH BLOOD LEVELS OF URIC ACID AMONG PAKISTANI CITIZENS

AUTHORS:

Muhammad Umar Ramzan, Atif Rasool, Kashif Sardar

ABSTRACT:

Objective: To determine the connection between hypertension and high levels of uric acid in the blood among the citizens of Pakistan. Study design and duration: This is a prospective analysis that was initiated in august 2018 and completed in March 2019 after eight months. Setting: This study was held in the Mayo Hospital Lahore. Patients and methods: All patients with high blood uric acid levels reported to the hospital under study were included in this study. The two groups of patients have been made. WHO calculator has been used to calculate the sample size. Group A was made of patients with high blood pressure, while group B was made of patients having normal levels of blood pressure. There were 150 patients in a single group and a total of 300 patients. According to inclusion criteria, the fasting level of uric acid in the blood should be increased; the blood pressure should be more than usual depending on the age of 3 different days per week. A pre-designed proforma was used to document all the collected data. Calculations were made using version 24 of the SPSS software. Results were determined as an SD for quantitative variables, a percentage for qualitative means and variables was calculated. P-values of 0.05 or less than that were considered to be significant. The interval of confidence was 95 per cent, with an error margin of 5 per cent. Results: There were a total of 300 cases involving 155 male patients (51.7%) and 145 female patients(48.3%). In group-A with patients of hypertension, 45 were male patients (15 per cent), and 105 were female patients (35 per cent). While in patients of group B with normal levels of blood pressure, 110 were male patients (36.7 per cent), and 40 were female patients (13.3 per cent). The patients were of 20 to 80 years of age, having a mean age of 46.78±8 years old. In patients of group A with hypertension, 73 patients (24.3 per cent) had hyperuricemia. In the patients of Group B, 5 out of 150 patients (3.3 per cent) had hyperuricemia, including four male patients (2.7 per cent) and one female. Conclusion: There is a close correlation between hyperuricemia and patients with hypertension among the population of Pakistan and most frequently among the female population.