- CODEN : IAJPBB
- issn 2349-7750
TITLE:
EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF THE EXTRACT VICOA INDICA (L) AGAINST CCL4-INDUCED HEPATOTOXICITY IN ALBINO WISTAR RATS
AUTHORS:
Prasanth AR* , Jaslin Edward , Rakesh kumar Jatt*
ABSTRACT:
The current study intended to determine the hepatoprotective activity of an extract of Vicoa indica (VI) leaves using recognized rat models. Seven groups of rats (n = 5) were divided and Group I treated an administration of Saline 1ml/Kg and Olive oil (3ml/Kg) weekly twice orally for 4 weeks (control), Group II induction of hepatotoxicity using carbon tetrachloride CCl4 30% in olive oil (3 ml/Kg) oral route, Group III Silymarin 100mg/Kg at oral route weekly twice for 4 weeks. Group IV CCl4 30% in olive oil (3 ml/Kg) oral route, Ethyl acetate extract low dose at oral route weekly twice for 4 weeks, Group IV CCl4 30% in olive oil (3 ml/Kg) oral route, Group V Ethyl acetate extract high dose at oral route weekly twice for 4 weeks, Group VI CCl4 30% in olive oil (3 ml/Kg) oral route, Methanol extract low dose at oral route weekly twice for 4 weeks CCl4 30% in olive oil (3 ml/Kg) oral route, GroupVII Methanol extract high dose at oral route weekly twice for 4 weeks. After last dosing Blood samples and liver specimens were collected for biochemical and histopathological analysis. The result was revealed that VI exhibited a significant (p < 0.05) hepatoprotective activity against both inducers and test group compared with standard group which could be related to their phytochemical constituents and antioxidant property of the extract. Key words: Silymarin, hepatoprotective, phytochemical, Vicoa indica. antioxidant
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NLM ID:101711216 [Serial]
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