- CODEN : IAJPBB
- issn 2349-7750
TITLE:
COMPARATIVE STUDY OF SUSTAINED VIRAL RESPONSE AT 12 WEEKS (SVR-12) AFTER TREATMENT WITH COMBINATION OF VELPATASVIR 100MG AND SOFOSBUVIR 400MG AMONG NON-CIRRHOTIC AND CIRRHOTIC PATIENTS AT JINNAH HOSPITAL LAHORE
AUTHORS:
Dr. Ayesha Akram, Dr. Mehreen Naz, Dr. Eram Najm
ABSTRACT:
Introduction: Globally, viral hepatitis C is a significant public health issue with an expected 71 million individuals suffering from hepatitis C around the world[1]. The menace of Hepatitis C is the leading cause of liver failure and liver cancer in 30% to 50% of infected patients worldwide[1,2]. Pakistan carries one of the world's highest burden of end stage liver diseases and mortality due to liver failure and liver cancer, which affects 6 per 100,000 males and 4 per 100,000 females[3]. With an expected prevalence of 4.5-8.2%, Pakistan has the second highest prevalence of hepatitis C after Egypt. Methodology: Setting: The Study was done at Jinnah hospital Lahore. Sample size: 93 case of hepatitis C positive pcr was included in the study. Sample Selection: Consecutive non-probability sampling Study design: Randomized control trail Study setting: The study was conducted at hepatitis clinic, department of medicine Jinnah Hospital Lahore. Data Collection All the patients was initially screened by rapid testing device (RTDs) for hepatitis C. The patients tested positive for hepatitis C in initial screening was further advised blood sampling for qualitative polymerase chain reaction (PCR) test. Results: 95% of non-cirrhotic patients had achieved SVR whereas 89% of cirrhotic patients has achieved SVR. 5% of non-cirrhotic patients had not achieved SVR whereas 11% of cirrhotic patients had not achieved SVR.
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NLM ID:101711216 [Serial]
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