::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

CUBOSOMES - ADVANCED DRUG DELIVERY SYSTEMS: A REVIEW

AUTHORS:

Blessy M.R*, SubashChandran M.P, Prasobh G.R, Remya S.B, Aparna P

ABSTRACT:

Cubosomes are self-assembled liquid crystalline particles. They are formed by dispersion of bicontinuous cubic liquid crystalline phases.Cubosome are honey comb like structure.Cubic liquid crystals are physically transparent and isotropic phases that are stable in excess water and show a unique system for the production of pharmaceutical dosage forms. The liquid crystals of cubic phase are used in the controlled release of selected water and oil soluble molecules. Cubic phases have a thermodynamically stable structure consisting of two separate, continuous but non intersecting hydrophilic regions divided by a lipid bilayer. This allows the incorporation of hydrophilic and hydrophobic materials and also amphiphilic materials into the system. Lipid based cubic system is biocompatible, and bio adhesive. Mainly two methods are employed for the preparation of cubosome, they are top- down technique and bottom -up technique. Key words: Cubosome, Honeycomb, Hydrophilic, Hydrophobic, Drug delivery systems.