::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

STUDY OF STONE FORMATION ASSOCIATED URINARY TRACT INFLAMMATION AND METABOLIC DISORDERS

AUTHORS:

Sher Muhammad Khan, Muhammad Waqas, Muhammad Ahmed Khan

ABSTRACT:

Objective: The main objective was to establish the association between the development of stones in metabolic diseases and the urinary tract inflammation caused by them. Place and duration of study: This study was performed in Nishtar Hospital Multan's urology department over nine months from March 2020 to November 2020. Materials and methods: This research involved a total of 100 patients. Both genders were randomly picked. The urine sample, which was then sent to a reputable laboratory to examine specific gravity, pH, uric acid, creatinine, calcium oxalate, phosphate, magnesium, and citrate, was collected by each patient for 24 hours. Each patient's thorough history was taken. To collect the samples, plastic boxes that were inert were used and then stored at 2-8 oC. Samples of blood were also sent to search for creatinine, phosphate, urea, uric acid, and calcium levels. Results: Of the 100 selected patients, 65 were female, and 35 were male, with a mean age of 38 years. The lumbar pain complaint accompanied by burning micturition and hematuria was presented by 79 per cent of patients. Ninety-four per cent of the patients were diagnosed with ureteric renal stones. In 38 per cent of the cases, the real stone formation was seen, while 62 per cent of patients suffered from it for the first time. After extensive chemical analysis, calcium oxalate was seen in 82.5 per cent of the cases. Conclusion: Results of the study showed that those patients who have metabolic abnormalities, have a high incidence of stone formation and stone formation is also high in patients who have hyperoxaluria, hypocitraturia, are the common abnormalities seen.