Dr Zain Ali Pattal, Dr Muhammad Zeshan Siddique, Dr Ateeb Ali Choudhary
Background: Systemic lupus erythematosus (SLE) is a chronic, auto immune disorder and multisystem. This disease is non-predictable and its nature is episodic. Its severe complication includes Kidney inflation. Material and Methods: For the research purpose 43 cases were short listed with an incidence of III/IV lupus nephritis. These patients visited OPDs and clinics from January, 2016 to October, 2017 with an additional 6-month follow-up. Nine of them were treated with mycophenolate and remaining thirty-four were treated with cyclophosphamide. At the end of six months’ proteinuria and glomerular estimation of filtration rate was administrated in the patients. Response was also calculated in the patients. Results: Complete or partial response was observed in the 44 percent of the cases in the six months’ duration whereas 64 percent of the cases were noted for their response at one year. Factors linked with the response of six months include old age at the time of diagnosis, hypertension, activity, time frame of indications before therapy and chronicity indices. Hypertension and chronic index are indicators of logistic regression response at the time of six months. Our research paper the cases of proliferative lupus represent lower rate if proteinuria, eGFR and elevated scores of chronicity when compared to African-American and Caucasian cases. Associated factors with response at six months include old age at the time of diagnosis, hypertension, activity, time frame of indications before therapy and chronicity indices. In Caucasian case similar short-term results were observed. Keywords: Systemic Lupus Erythematosus, Chronic, Immune Disorder, Kidney Inflation.