Rathinasamy Periasamy, Nikodimos Eshetu Dabe
One of the biggest public health disasters of recent times is none other than COVID-19 caused by the novel coronavirus named as SARS-CoV-2, cause an acute typical respiratory disease. The zoonotic virus transmittable between humans has caused pandemic worldwide still not came to end and cause the major mortality rate globally. There is a range of clinical features from mild to severe life-threatening disease with major complications like severe pneumonia, acute respiratory distress syndrome, acute cardiac injury and septic shock. The mortality rate of different countries forced the government to enforce public social distancing and many versions of lockdown. Lack of specific drugs and vaccine continues the chaotic situation in every sector of a nation. Epidemiological studies showed that elder patients were more vulnerable to severe diseases, while children and middle-age tend to have milder symptoms. In this review, deals with the riddles of COVID-19 based on the current reports of transmission and pathogenesis and contemplate the various factors behind the higher mortality rate in adults. Keywords: Transmission, Pathophysiology, COVID-19, Complications, Mortality rate.