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TITLE:

THE PREVALENCE OF BREAST DISEASES AT KING ABDULAZIZ UNIVERSITY HOSPITAL: SCREENING AND COST EFFECTIVENESS.

AUTHORS:

Fadwa J. Altaf , Ragad S. Jamal, Maryam H. Habib, Shahad J. Al-Aslany

ABSTRACT:

Objective : Our objective is to identify the pattern of breast diseases at our institution and compare the findings with similar studies from the region in order to determine if our population will benefit from early breast cancer detection programs and its cost effectiveness. Introduction: Benign breast diseases are very common in comparison to the malignant counterpart. Proliferative, non-proliferative and carcinoma in situ categories are recognized to carry some risk to the patients harbouring them to develop invasive breast cancer. Methods: All breast cases in the archive of the department of pathology from January 2010 till December 2013 were reviewed. Inclusion and exclusion criteria were identified. Results: 1375 cases were identified, 398 were excluded. A total of 977 cases were included in the study,963 cases were female (98.6%) and 14 male cases (1.4%). Benign diagnosis were 647(67%) of which non-proliferative diseases including , Fibrocystic changes, inflammatory changes and Fibroadenoma comprise 515 cases (53.5%) and Proliferative disease without atypia comprise 101 cases (10.4%), while Proliferative disease with atypia comprise 31 cases (3.2%). Carcinoma in situ were 113 cases (11.7%). The invasive malignancy cases were 448 (46.5%).176 cases (18.1%) had more than one diagnosis in their biopsies. The benign to malignant ratio is 1.2:1 All male lesions were comprised of : Epithelial hyperplasia without atypia 1 case (7.1%), Fibrocystic changes 1 case (7.1%), Ductal carcinoma in situ 2 cases (14.3%), and Invasive ductal carcinoma 3 cases (21.4%). 9 cases had gynecomastia. The total combined diagnosis was 2 cases(14.2%). Benign to malignant disease ratio is close. This finding is different from the literature and from other studies published in 2004 from the same institution. The increase of malignant diagnosis might be related to the hospital setup as a referral center for breast disease and the utilization of its facilities for screening and early detection

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