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AMELIORATIVE EFFECT OF PHOENIX DACTYLIFERA (AJWA) ON RENAL BIOCHEMICAL MARKERS IN ALLOXAN INDUCED DIABETIC NEPHROPATHIC RATS

Dr. Iram Imran, Dr. Imran Maqsood Butt, Dr. Zulfiqar-ul-hassan, Dr. Sabiha Iqbal

Background: Dates specially date seeds have shown their preventive effects in controlling hyperglycemia in diabetes mellitus in few recent studies, however there is need to explore the effects of dates on its complications. Objective: This study was planned to evaluate the preventive effect of whole Ajwa date on nephropathy in alloxan induced diabetic rats Methods: Whole ajwa date powder mixed in rat chow was administered to male sprague dawley rats after induction of diabetes with alloxan monohydrate for 6 weeks. Serum and urine biochemical parameters were assessed by enzymatic methods. Results: Oral administration of ajwa date diet significantly ameliorated the elevated levels of fasting blood glucose (167.0 ± 37.5 versus 353.8 ± 67.5 mg/dl), urea (41.3 ± 13.5 versus 75.1 ± 11.2 mg/dl), creatinine (0.49 ± 0.2 versus 0.99 ± 0.2 mg/dl), microalbuminuria (7.4 ± 1.9 versus 14.6 ±1.7 mg/l ), improved the lowered levels of body weight (202.0 ± 40.7 versus 143.8 ± 21.7g), urinary creatinine (13.8 ± 2.3 versus 7.0 ± 1.6 mg/dl), and creatinine clearance (0.195 ±0.1versus 0.55 ± 0.01ml/min) compared with the untreated diabetic rats. Discussion and conclusion: The ajwa date powder showed potential protective effects against early diabetic complications of kidney. This effect may be explained by the antioxidant and free radical scavenging capabilities of P. dactylifera. Keywords: Antihyperglycemic, antioxidant, ajwa date, diabetic nephropathy, alloxan. Abbreviations: Diabetes Mellitus (DM); Fasting blood sugar (FBS); 2,2-diphenyl-1-picrylhydrazyl (DPPH); 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid (ABTS)

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