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TITLE:

STUDY TO KNOW THE PREVALENCE OF THYROID DYSFUNCTION IN PATIENTS OF DIABETES MELLITUS

AUTHORS:

Dr. Nisar Haider Anjum, Dr. Sana Musaddiq, Dr. Mariam Zakia Chaudhari, Dr. Sana Iqbal Bokhari

ABSTRACT:

Objective: To know the thyroid disease prevalence and its association with diabetic complications in diabetic patients. Study design: A descriptive study. Place and Duration: In Jinnah Hospital Lahore for one year duration from September 2017 to September 2018. Methods: The study included 100 patients with diabetes mellitus (DM) aged over 12 years of age. All diabetics were tested for TFTS including T3, T4 and TSH. A detailed examination and clinical history was performed to determine the signs and symptoms of thyroid dysfunction and its relation with DM complications. Other examinations were: CBC, blood glucose level (BSF and 2 hours postpartum), urinalysis, HbA1C, ECG, chest X-ray, blood urea, serum creatinine, fasting lipid profile and liver function tests. Echocardiography was performed when urinary ketones, Doppler studies, serum electrolytes and arterial blood gas analysis were reported for peripheral vascular disease. The data were analyzed using SPSS 18 and the in terms of descriptive statistics results were recorded. The percentage and frequency were checked and the standard deviation was determined. The p <0.05 was static significant. Results: In the study 100 total patients were selected. The male were 51% and female were 49%. The 16 to 70 years was the age range (mean, 55 years). 13% had type 1 DM, 87% had type 2 DM and 14% had thyroid dysfunction. The subclinical hypothyroidism was noted in 5 of them, hypothyroidism in 4 patients, hyperthyroidism in 3 and subclinical hyperthyroidism in 2. The thyroid dysfunction prevalence in diabetic patients; complication was 14.4% of those with ischemic heart disease, 12.8% with neuropathy, 13% with peripheral vascular disease, 16% with retinopathy, 12.7% with nephropathy and 9% with hypoglycemia and diabetic foot 33.3%. Conclusion: In diabetic patients; Thyroid dysfunction is common and can make significant metabolic changes. Key words: Hyperthyroidism, diabetes mellitus, hypothyroidism.

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