ResearcherID - CLICK HERE Scientific Journal Impact Factor (SJIF-2020) - CLICK HERE

ANALYSIS OF LEVELS OF ANTIOXIDANTS IN THE BLOOD WITH THE USE OF ROPIVACAINE FOR GENERAL ANESTHESIA

Dr Samra Gull, Dr Waqas Anjum, Dr Abdul Hannan Javaid

Introduction: There are a variety of studies investigated the differences between general anesthesia (GA) and spinal anesthesia (SA) concerning different aspects such as patient satisfaction, cost-effectiveness, postoperative hospital stay, postoperative pain scores and analgesic requirements, acid-base status, as well as their effects on serum concentration of pro-inflammatory and anti-inflammatory cytokines. Objectives of the study: The main objective of this study is to find the level of antioxidants in blood with the use of Ropivacaine for General Anesthesia. Materials and methods: This cross sectional study was conducted at Nishtar Hospital, Multan during October 2018 December 2018. 50 patients were selected to study the effect of ropivacaine. 5.0 ml blood sample was taken to measure the levels of lipid peroxidation (MDA), glutathione (GSH), SOD and Catalases before anaesthesia (0 min), and at 5, 30 and 60 minute after anaesthesia. Commercially available enzymatic kits of Randox were used. Results: Mean values of investigated parameters and differences in the values between, before and after anaesthesia are represented in the table 01. The values are expressed in terms of mean± SD. According to the analysis, the level of SOD, MDA and GSH increase as compared to normal level. But the level of catalases decreased with the value of 0.43±0.39 (after 5 minutes of anaesthesia). Conclusion: In conclusion, we found that while spinally injection of ropivacaine increased free radical levels in the blood.

FULL TEXT