ResearcherID - CLICK HERE Scientific Journal Impact Factor (SJIF-2020) - CLICK HERE

COMPARISON OF TWO METHODS OF TRANSFUSION THERAPY FOR STROKE PREVENTION IN SICKLE CELL

Dr. Abdul Manan, Dr. Waleed Asghar,Dr. Muhammad Arslan Mumtaz

Chronic blood transfusions are very important in the care of sickle-cell patients in danger for morbidity and death caused by stroke. In the thorough sickle cell center, researcher assist chronic transfusion using rapid manual partial exchange transfusions (RMPET) working with a particular access fundamental line port. Researchers have no detailed adult sickle cell program mostly in the hospitals, however upon transition of patients to the adult transfusion clinic they might be supplied simple transfusion (ST) rather than exchange. Since researchers employ a smaller sickle cell population without having erythrocytapheresis functionality, researchers examined whether switching their patients to simple transfusion is going to be viable lacking limiting their haemoglobin S measurement variables or ferritin levels. To review the patients on chronic transfusion support and evaluate the variety of strategies to better recognize the effects from switching from RMPET to ST. We utilized a potential observational cohort design to work out that technique for transfusion was ideal for reducing haemoglobin S measurement. A crossing over design was adopted so that every patient served as its personal control. Nine subjects around the age groups of 4 years to 23 years were part of the research of 10 chronically transfused patients. Accordingly, 8 of 9 subjects experienced Sickle cell SS hemoglobinopathy and 1 had S Beta° Thalassemia. Researchers likewise interviewed patient inclination for every transfusion mode and care-giving opportunity to perform the transfusion. A Wilcoxon signed-rank test decided that there had not been a statistically important median difference in Hb S by the end of the transfusion, each method achieving Hb S<30%. There had been also no statistically important median difference in Ferritin levels. The center has preferred to replace the transfusion exercise to straight transfusion and not RMPET that will be additional time ingesting. Patients were additionally delighted by the straight transfusion technique. Nursing staff was appreciative with the shorter transfusion times. The outcomes may possibly support some other smaller programs decide to use straight transfusion instead than rapid manual partial exchange to use on their chronically transfused patients. Keywords: Chronic transfusion therapy; Sickle cell disease; Stroke prevention.

FULL TEXT