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TITLE:

PREVALENCE OF MULTIPLE BLOOD TRANSFUSIONS RELATED COMPLICATIONS AMONG THALASSEMIA MAJOR PATIENTS.

AUTHORS:

Dr. Hafiz Abdul Haseeb, Dr. Nurmeen Ayaz, Dr. Muhammad Adil Khan

ABSTRACT:

Background: Thalassemia major patients require multiple blood transfusions in their life. The blood transfusion related infections are viral hepatitis B and C, HIV. Objective: The purpose of this study is to find out the prevalence of these transfusion related infections among thalassemia major patients. Materials and methods: this study was conducted over period of 15 months at Govt. Nawaz Sharif Hospital, Lahore. It is a descriptive, cross sectional study. 211 thalassemia major patients who underwent multiple transfusions were selected and were screened for transfusion related infections, hepatitis B and C pus HIV. Results: there were 151 females and 60 were males, out of 211 sample size. It was observed that patients who underwent more frequent or multiple blood transfusions suffered transfusions related infections more commonly. No relation between gender, age and risk of infections was observed.10 to 100 transfusions were received by 70 patients (33.1%), 47 had received 101 to 200 transfusions, 55% patients had transfusions from 201 to 300. 48% had transfusion from 301to 400. 66.6% patients had more than 400 blood transfusions. Seropositivity of blood transfusion related infections was commonly seen among these patients. Conclusion: Thalassemia is a chronic disease which requires multiple blood transfusions, treatment complications are iron overload, leading to iron accumulation in multiple organs and increasing risk of morbidity and mortality. In addition, transfusion related infections like hepatitis B, C and HIV are commonly seen in these patients. Risk of these complications increases with increased number of transfusions. These infections can be reduced by proper screening of donors and blood before transfusion. Key Words: Thalassemia Major, Blood Transfusions, Infections, Complications, Screening.

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