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CLINICAL MANIFESTATIONS OF FALCIPARUM MALARIA

Dr. Ghulam Shabir Laghari, Dr. Naveed Aslam Lashari, Dr. Imran Karim Dr. Hamid Nawaz Ali Memon, Dr Almas Jahejo and Dr. Ali Raza Shaikh

OBJECTIVE: To determine the clinical manifestations of children with falciparum malaria PATIENTS AND METHODS:The six months cross sectional study was conducted on children with falciparum malaria of either gender having history of fever for last five days with peripheral smear (thick /thin) or immunochromatographic antigen detection assay positive for plasmodium falciparum. Detailed physical examination included assessment of general physical condition, vital parameters, anthropometry, pallor and jaundice. Systemic examination included central nervous system, respiratory, cardiovascular system and abdominal examination to assess hepatomegaly and splenomegaly while all the relevant investigations were advised accordinglwhile the frequency / percentages (%) and means ±SD computed for study variables. RESULTS:During six month study period total fifty children had falciparum infections were explored thoroughly. The frequency for male and female population was 35 (70%) and 15 (30%) with mean ± SD for age of male and female individuals was 33.87±9.724 (months) and 37.87±6.95 (months) respectively. Gender male 35 (70%), female 15 (30%), residence urban 17 (34%) and rural 33 (66%) while the clinical manifestations includes cerebral malaria 20 (40%), respiratory distress 25 (50%), convulsions 28 (56%), acidosis 11 (22%), severe anemia 37 (74%), hypoglycemia 20 (40%), renal failure 15 (30%), DIC 05 (10%), pulmonary edema 06 (12%), circulatory collapse 09 (18%), hyperparasitemia 06 (12%) and jaundice 08 (16%) CONCLUSION:Malaria has reemerged as a major public health problem while the severe anemia, convulsions, cerebral malaria, hypoglycemia and respiratory distress are the commonest manifestations of severe malaria. KEYWORDS:Malaria, falciparum and parasite

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