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ROLE AND MECHANISM OF STABILIZERS IN NANOSTRUCTURED LIPID CARRIER

Rajveer Bhaskar, Monika Ola, S.S. Chalikwar and Iqbal Ahmad,

Nanostructured lipid carriers (NLC) are second generation lipid nano carriers. that is one of the promising nano-carriers that develop the effective targeted therapies. Solid lipid and liquid lipid which is bio-compatible and/or bio degradable used as a core matrix dispersed in stabilizer solution. However, despite the considerably simple structure, the assortment of good stabilizer for a certain drug is a challenging task because they are maintaining the nanosized particle size as long as possible after the formation of NLC. The bioavailability is also affected in the final formulation by cells and cell layers interactions that are maintained by stabilizers. This review describe the types of NLC, techniques to prepare NLCs and their advantages with limitation, Application of Stabilizers in different dosage form, classification of stabilizers, practical consideration for the selection of stabilizers and mechanism of stabilizer which is steric, electrostatic and electrosteric Keywords: Nanostructured lipid carrier, stabilizers, mechanism, electrosteric, application

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