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CHANGES IN SODIUM LEVEL AFTER SURGICAL TREATMENT OF BENIGN ENLARGEMENT OF PROSTATE

Imran Memon, Dr. Syed Azhar Hussain, Dr Shoukat Mughal

Cancer in a global threat as it is considered the primary cause of death worldwide. Breast cancer is the most common cancer I female worldwide. In the present study we evaluated the role of temozolomide, carboplatin, sodium phenylbutyrate, and cyclophosphamide in changing the methylation landscape of four tumor cell liness; breast, colorectal, lung, and cervical. Cells were treated with 5 µM of each drug and the cells were incubated with the drugs for 48 and 96 h before reading the changes in methylation patterns. Global methylation quantification was measured in cells after being treated with the drugs. Data obtained indicated that sodium phenylbutyrate, followed by temozolomide were the drugs most efficient in hypermethylation of the DNA, while carboplatin followed by cyclophosphamide were able to reduce the concentration of 5-mC in the DNA. It has been concluded that using carboplatin in combination with sodium phenylbutyrate (PBA) might induce cell cycle arrest of malignant cells. Further studies are needed to highlight the mechanism of action of these drugs when combined in treatment of cancer. Keywords: methylation; breast; colon; lung; cervical; epigenetics. Objective: To assess the changes in sodium level after surgical treatment of benign enlargement of prostate Study Design: Descriptive case series Place and Duration: Asian Institute of Medical Sciences from January 2018 to July 2018. Materials and Method: Total 75 patients with BPH were included. Blood sample was obtained for baseline serum sodium level. Patients were undergoing TURP. After 24 hours of surgery, again blood sample was obtained for assessment of serum sodium level. Mean change in serum sodium was noted. Comparison for mean change was done by using t-test. Stratification was done. P-value ≤0.05 was considered as significant. Results: The overall mean age was 59.58±7.02 years. Mean duration of symptoms was 6.94±1.18 months. Mean resected tissue weight was 44.26±8.01 grams. Mean sodium change was decrease to 1.21±2.04 meq/I. There was significant difference in mean serum sodium at baseline with after 24 hours. Conclusion: There was significant mean change in serum sodium after 24 hours of TURP. So the need for monitoring electrolyte following TURP should be individualized. Keywords: Mean Change, Serum Electrolyte, Benign Prostate Hyperplasia, Transurethral Resection Of The Prostate.

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