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FORMULATION AND INVITRO EVALUATION OF ROSUVASTATIN CALCIUM SOLID DISPERSION

T. Sravani, T. Balakrishna, V. Akash, S. Srinivasa Rao, A. Tejaswi, T. Navya Sri,M. Raga Mallika, A. Indira

Rosuvastatin calcium (RST) is a selective and competitive inhibitor of HMG-CoA reductase, mainly used in the treatment of hypercholesterolemia, hypertriglyceridemia and atherosclerosis. In this work a new attempt was made to enhance the solubility, dissolution rate and oral bioavailability of poorly soluble rosuvastatin by formulating it as solid dispersions using various techniques with polyethylene glycol (PEG) 6000 as a carrier. Solid dispersions were prepared by physical mixing, kneading and solvent evaporation methods using PVP K-30 as a superdisintegrant at different ratios were found to be stable and suitable for increasing the dissolution rate of Rosuvastatin. 1:2 ratio of drug and superdisintegrant respectively in every method showed highest rates of dissolution than the other ratios i.e., as superdisintegrant concentration increases the drug solubility increases. Formulations were evaluated for physical parameters and drug release by in vitro dissolution studies. drug-excipient interactions FTIR studies. Key Words: Rosuvastatin calcium, PEG 6000, Sodium starch glycolate, Poly vinyl Pyrrolidone, Pregelatinized starch, Mannitol.

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