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RISK FACTORS AND DEMOGRAPHIC CHARACTERISTICS FOR HEPATITIS DUE TO MEDICATION IN PATIENTS OF TB

Dr. Fakhra Bashir Khattak, Dr. Hira Jamil, Dr. Syeda Makhduma

Objective: This study was aimed to know about risk factors and demographic characteristics for anti-tuberculous drugs influence hepatitis (ATDH) amongst tuberculosis patients. Study Design: A retrospective study. Place and Duration: We held this study by collecting the patients’ data of 03 years from January, 2016 to December, 2018 at Gastroenterology and Pulmonology department of Mayo Hospital, Lahore. Methodology: The medical records of tuberculosis 3060 cases were reported for three years was collected and data analyzed for ATDH. Written permission was taken from the ethical committee of Hospital. TB inclusion criteria identified based on the National Tuberculosis Program (NTP) was documented. ATDH and Non-ATDH data was analyzed in the SPSS-20 and full fisheries and chi-square tests. Results: A total of 153 cases were diagnosed as ATDH which comprise of51 (33.33%) females and 102 (66.67%) males, 43.20 years was the mean age, SD 9.50 treatment and ATDH as follow up period were selected for the study. ATDH in patients was found to be significant statistically (P=0.0001, OR: 13.92) (OR: 7.6, P=0.0002) and (OR: 11.3, P=0.0001) was the difference among intravenous injection ATDH and HIV infection. Conclusion: ATDH had the maximum prevalence among patients suffering from HCV, HIV and IVDU infection. Key words: ATDH, tuberculosis, drug-induced hepatitis, national tuberculosis program (NTP).

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