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TITLE:

THE RELATIONSHIP BETWEEN SLEEP DURATION, DINNER TO BEDTIME, AND COLORECTAL CANCER: A REVIEW OF THE LITERATURE

AUTHORS:

Hyder Osman Mirghani, Mowffaq Mohammed Kalantan

ABSTRACT:

Objectives: There is an increasing awareness regarding sleep duration and colorectal cancer, in the current review we assessed the relationship between sleep duration, dinner-to bedtime to colorectal cancer. Methods: Eligibility criteria were human studies in English language assessing the effects of sleep duration, dinner-to bedtime on colorectal cancer. An unlimited manual search in PubMed and Google Scholar was conducted using the terms sleep duration, short sleep, prolonged sleep, dinner-to bedtime, and colorectal cancer. Among the 175 articles identified, 20 full texts were assessed and 12 human studies were included. The author name, year of publication, country, methods of the study, number of patients, duration of the study, and the conclusions were reported. Results: Out of the twelve studies included (33.3% were from the USA, 33.3%from China, and 33.3% were from Europe), nine studies assessed sleep duration all of which except two showed an association with short sleep duration (<7 hours) and prolonged sleep (> nine hours) with colorectal cancer and three investigated the prognosis among colorectal cancer patients and showed an inverse relationship between abnormal sleep and mortality and response to chemotherapy. Conclusion: An association of sleep duration (prolonged or short), daytime sleepiness, short dinner-to bedtime, and colorectal cancer was found. Raising the awareness of both the patients and the treating doctors about good sleep hygiene effects on colorectal cancer is recommended. Keyword: Sleep duration, Short Dinner-to bedtime, Colorectal cancer.

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