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Dr. Munazza Iftikhar, Dr Durre Shawar, Dr Nabi Ahmad Chatha


Objective: To determine the metabolic irregularities in the serum and urine of patients with urinary stones disease. Methods: Fifty patients were evaluated having multiple or recurrent urinary stones, diagnosed on ultrasonography and IV urography were involved in this study. 24-hour urine sample was collected from all of the patients and got Creatinine, uric acid, calcium, phosphate, oxalate levels. Furthermore, blood sample of every participant was also taken for serum levels of urea, creatinine, uric acid, phosphate and calcium. Results: Average age of patients was 31 ± 9.46 years with male to female ratio of almost 4:1. The chief presenting complaint was pain in lumber region and 43 (86%) patients were found to have calcium oxalate stones on chemical analysis. Metabolic abnormalities were found in 46 (92%) patients, while there was no metabolic abnormality seen in 4 (8%) patients. 10 (20%) patients had only a single metabolic abnormality while 36(72%) patients were having multiple metabolic abnormalities. Hyperoxaluria was commonest metabolic abnormality noted and was present in 33 (66%) patients. Other significant metabolic abnormalities were hypercalciuria, Hypercalcemia, hypocitraturia and hyperuricemia. Conclusion: Conclusion to this study is that the frequency of metabolic abnormalities is significantly higher in patients with urolithiasis and hyperoxaluria, hypercalciuria and hypocitraturia are vital metabolicabnormalities noted in these patients. KEY WORDS: Urolithiasis, Metabolic evaluation, Hyperoxaluria.

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