ResearcherID - CLICK HERE Scientific Journal Impact Factor (SJIF-2020) - CLICK HERE

VALUATION OF GLYCEMIC CONTROL, RED CELL DISTRIBUTION WIDTH AND DIABETES RELATED COMPLICATION

Dr Imran Joher, Dr Aftab Rabbani, Dr Mohammad Atiq Ur Rehman

Aim: To assess the relationship between the red blood cells distribution width and glycemic control and the presence of complications in patients with diabetes. Study Design: A Cross-Sectional Study. Place and Duration: In the Medicine Unit of Sharif Medical City Lahore for one year duration from May 2018 to May 2019. Methods: 300 total patients with diabetes mellitus type II were selected for the study. Clinical and demographic features were documented and complete blood counts were performed. The distribution width of red blood cells, glycosylated hemoglobin, fasting and random sugar, lipid profile, urea and creatinine. The presence of complications was assessed during a clinical trial. SPSS 21.0 was used for data analysis. Results: There were 300 middle-aged patients with 54.20 ± 12.07 mean age. The diabetes mean duration was 7.40 ± 5.50 years and the mean glycosylated hemoglobin was 8.85 ±1.23. Red blood cell distribution was related with diabetes duration, hypertension, macro vascular and microvascular complications, and glycemic control (each p <0.0001). A statistically significant linear relationship was observed between the distribution of red blood cells and the number of macro vascular and microvascular complications (p <0.0001) and glycosylated hemoglobin (p <0.0001). The mean width of red blood cell distribution was 14.54 ± 1.50, 15.02 ± 1.40 and 14.80 ± 1.60, respectively, for optimal control, border control and weak control. This linear growth pattern was statistically significant (p <0.0001). Conclusion: The linear relationship between the RDW and glycosylated hemoglobin may allow its use as a measure of hyperglycemia. Key words: RDW, HbA1c, diabetic complications, glycemic control, type 2 diabetes.