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ANALYSIS OF MECHANISM OF GENETIC POLYMORPHISMS WITH THE ASSOCIATION OF BLOOD TRANSFUSION IN HUMAN LEUKEMIA DISEASE

Maryam Rafaqat Hussain, Syed Mohsin Mehmood, Hira Ayub

Objectives: The main objective of this study is to find the mechanism of Genetic polymorphisms with the association of blood transfusion in human leukemia disease. Material and methods: This descriptive study was conducted in Icahn School of Medicine Mount Sinai, New York USA during March 2019 to November 2019. All histologically confirmed cases of leukemia diagnosed from 2015 to 2013in a Shalimar hospital was selected for study. Enrollment criteria include the age between 20 to 50 years. Pathology slides from all patients were obtained from the original pathology departments and reviewed by two independent pathologists. All cases in this study were classified according to the World Health Organization classification system. Results: Blood transfusion is not associated with the risk of leukemia. According to data CLL is not related to blood transfusion (OR=0.7 at 95% CIL) and DLBCL (OR=0.9 at 95% CIL). Conclusion: Our results suggest that genetic polymorphism in TNF gene modifies the association between blood transfusion and risk of leukemia B-cells.