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THE EFFECTS OF RED ONION’S EXTRACT ON OVARIAN HISTOLOGY OF LABORATORY MICE

Neda Mannani , Mehrdad Modaresi *

Onion is a plant from the Aliaceae family with numerous medical uses. Current study was carried out to investigate the effects of red onion extract on ovarian histology of female mice (Balb/C race). Mice were divided into five groups after regulating the sexual cycle (control, placebo and the extract in of 50, 100, 200 mg/kg amounts). The extract was injected intraperitoneally every other day for 20 days. The control group received no medication and the placebo group received only physiological serum. After dissection, the tissue sections of the ovaries were prepared and examined by light microscopy. Results of ovarian histology showed a significant decrease in the number of Graafian follicle in second group, a significant decrease in the number of corpus luteum in second and third groups, a significant decrease in Graafian follicle diameter in first and third groups, and a significant increase in oocyte diameter of second group. According to the results obtained, red onion’s extract disrupts folliculogenesis and can reduce fertility dose dependently. Keywords: Red Onion, Oocyte, Graafian follicle, Folliculogenesis, Corpus Luteum, Mice