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IMPACTS OF CABERGOLINE MANAGEMENT ON UTERINE BLOOD FLOW AMONG FEMALES PRESENT WITH POLYCYSTIC OVARY SYNDROME

Dr Shamaila Doggar

Objectives: The purpose of this study is to find out the impacts of the cabergoline management on uterine perfusion among females present with Polycystic Ovary Syndrome. Methodology: 40 females were the participants of this research work. We divided the patients into two groups with twenty patients in each. All the patients were present with Polycystic Ovary Syndrome. The Polycystic Ovary Syndrome standard included amenorrhea, results of laboratory depending upon the rise of the androgen and then ultrasonography confirmed the present of polycystic Ovary Syndrome. Patient present with pregnancy, lactation or other serious diseases were not the part of this research work. After selecting both groups of placebo and intervention, we performed Doppler ultrasound for the patients of two groups. Then, we administered a weekly cabergoline dose of 0.50 mg to the patients of intervention group for a twelve weeks’ duration. We managed the patients of placebo group with placebo in the same manner. After the completion of twelve weeks, we performed Doppler ultrasound and we recorded the results into check lists. Results: There was no significant disparity in the patients of both groups regarding age, education level, profession, marriage duration, infertility type, Resistance Index findings and pulsatility-index before the intervention. Patients suffering from Polycystic Ovary Syndrome under Cabergoline management displayed significant rise in the blood flow of uterine. pulsatility-index was before 2.65 ± 0.52 and after 1.98 ± 0.52 and Resistance Index was before 0.85 and it was 0.77 after intervention, yet we found no difference in the patients suffering from Polycystic Ovary Syndrome having placebo treatment. Conclusion: There was more resistance in the blood flow of uterine in the patients of polycystic Ovary Syndrome as compared to the healthy population. However, administration of cabergoline proved to rise the blood perfusion of uterine and regulated the cycle of mensuration. KEYWORD: infertility, placebo, blood flow, perfusion, Polycystic Ovary Syndrome, resistance.