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PROTEIN NANOPARTICLE MEDIATED DRUG DELIVERY USING 5-FU PRODRUGS FOR THE TREATMENT OF GASTROINTESTINAL CANCER

Arjun Sai Sreekar Aeila*, Syed Tazib Rahaman, Tirandi Manohara Sai

Gastrointestinal cancer has been a problematic disease and the efficiency of treatment of gastrointestinal tract (GIT) cancers which had always been a complication. Tumor targeting is considered to be the most desirable property for treating GIT cancer. But according to various studies most of the drugs are found to be ineffective in one or other way to produce a prolonged release in tumor targeted drug delivery. Hence produgs of 5FU were considered in treatment of git cancer. The prodrugs of 5FU are further enhanced by using protein nanoparticles as drug delivery system. In this review we discussed about the various parts that git cancer can affect and the mechanisms of 5FU prodrugs, the synthesis of protein nanoparticles and the targeting achieved by using these protein nanoparticles. Keywords: Cancer; Neoplastic cells; Tumor targeting; Protein.