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STEM CELLS OF THE PERIODONTAL LIGAMENT: USE IN CLINICAL DENTISTRY

Shpitser Ivan Michailovich, Gazarian Aram Valerievich, Balobanova Natalya Petrovna, Chizhova Darya Sergeevna, Frolova Margarita Yurievna, Ilia Igorevich Dementev, Dereviankin Aleksandr Aleksandrovich, Rasamatov Bekhruz

This literature review contains information about discovery, markers and substances expressed by periodontal ligament stem cells (PDLSCs), about clinical experiments in vivo and in vitro studies, as well as on scaffolds used for cell transplantation, and the application of mesenchymal stem cell (MSC) data in general medicine. In recent years, tissue engineering has become increasingly popular in medicine and dentistry is not an exception. Many discoveries have already been made at the PDLSC gene level, which provide comprehension of certain differentiation processes, both in vivo and in vitro, and in ex vivo culture conditions. The niche of MSC data is easily available, therefore, for a number of other reasons, PDLSCs attract attention for use in regenerative medicine. Numerous clinical studies have shown the promise of use these cells for regenerative purposes. Key words: PDLSC, SC, regenerative medicine, Stem cells niche.